Comparison of Herpes Simplex Virus Reactivation Frequency in Acute Idiopathic Cranial Mononeuropathy and Normal Population by Serological Assay

Background: Herpes simplex virus (HSV) is a neurotropic DNA with high prevalence. Following primary infection, HSV remains dormant in the neural ganglia. Secondary infection can emerge after reactivation of latent presenting as neurological manifestations. Previous studies have demonstrated relationship between and selective involvement cranial nerves. Depending on affected nerve, mononeuropathies present symptoms, including diplopia, blurred vision, vertigo, unilateral facial palsy, speech impairment, swallowing difficulties, hoarseness. Objectives: This study used serological assay to compare frequency patients recent idiopathic normal individuals. Methods: Plasma samples from 35 mononeuropathy cases (57.2% women, mean age 58.37 years) sex-matched healthy controls were analyzed for anti-HSV immunoglobulin G (IgG) M (IgM) antibodies by enzyme-linked immunosorbent (ELISA). Results: Anti-HSV IgG antibody was positive 91.4% 88.6% controls. The serum level significantly higher (146.78 ± 60 RU/mL) than (130.61 52.99 (P-value = 0.037). IgM 37.1% 14.3% (P 0.042). Conclusions: acute controls, indicating possible role an etiology mononeuropathy.